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邵龙泉团队聚焦医用纳米材料的生物学效应展开系列研究

时间:2021-07-09 21:42:58  来源:   编辑:黄瑶  作者:  点击:

为了更好地了解医用纳米材料的生物学效应,邵龙泉团队对利用石墨烯及氮化镓等纳米材料改善骨缺损修复的应用价值及其分子机制进行了深入探讨,部分研究结果近期发表于Adv Funct Mater(IF 2020=18.808)、Bioact Mater(IF 2020=14.593)、J Nanobiotechnol(IF 2020=10.435)。此外,邵龙泉团队深入探讨了医用纳米材料在应用时可能产生的生物安全性风险,并剖析其毒性作用机制,取得了丰硕的研究成果。其中,两篇实验性论著近期发表于在环境科学领域TOP期刊J Hazard Mater(IF 2020=10.588);一篇实验性论著发表于纳米科技Q1分区杂志J Nanobiotechnol(IF 2020=10.435);两篇综述性文章分别发表在纳米毒理学领域TOP期刊Part Fibre Toxicol(IF 2020=9.400)及J Nanobiotechnol(IF 2020=10.435)。

生物学屏障作为纳米材料在应用时接触的第一防御机制,通过揭示纳米材料对其具体影响及分子学机制,能为纳米材料的安全应用提供科学依据。近日,邵龙泉教授指导的一篇综述性论著发表于药学领域TOP期刊Adv Drug Deliv Rev(IF 2020=15.470),另有一篇综述性论著发表在药学领域TOP期刊J Controll Release(IF 2020=9.776)。

以下为邵龙泉教授团队近期发表文章列表:

1. Zhang CG, et al. A Novel Approach to Enhance Bone Regeneration by Controlling the Polarity of GaN/AlGaN Heterostructures. Adv Funct Mater, 2021, 31(5): 2007487.

2. Kang YY, et al. Understanding the interactions between inorganic-based nanomaterials and biological membranes. Adv Drug Deliver Rev, 2021, 175: 113820.

3. Liu WJ, et al. Nanographene oxide-coupled endogenous lysophosphatidic acid promotes angiogenesis via Hippo-YAP1 signalling. Bioact Mater, 2021, Epub ahead of Print.

4. Feng XL, et al. Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells. J Hazard Mater, 2021, 416: 126158.

5. Lai X, et al. ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes. J Hazard Mater, 2021, 410: 124566.

6. Sun T, et al. Nanomaterials and hepatic diseases: toxicokinetics, disease types, intrinsic mechanisms, and liver susceptibility. J Nanobiotechnol, 2021, 19(1): 108.

7. Wang RL, et al. The mTOR/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles. J Nanobiotechnol, 2020, 18(1): 119.

8. Liu WJ, et al. Insights into the angiogenic effects of nanomaterials: potential applications and related mechanisms. J Nanobiotechnol, 2020, 18(1): 9.

9. Zhang C, et al. The interrupted effect of autophagic flux and lysosomal function induced by graphene oxide in p62-dependent apoptosis of F98 cells. J Nanobiotechnol, 2020, 18(1): 52.

10. Zhang YL, et al. Effects of carbon-based nanomaterials on vascular endothelia under physiological and pathological conditions: interactions, mechanisms and potential therapeutic applications. J Control Release, 2021, 330: 945-962.

11. Feng XL, et al. Nanomaterial-mediated autophagy: coexisting risks and benefits in biomedicine. Part Fibre Toxicol, 2020, 17: 53.

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